The haemostatic activity of chitosan can also be related to the presence of positive charges on chitosan backbone. Due to its positive charges, chitosan can also interact with the negative part of cells membrane, which can lead to reorganization and an opening of the tight junction proteins, explaining the permeation enhancing property of this polysaccharide.
Due to chitosan’s many attractive properties such as biodegradability, natural origin, abundance, reactivity, etc., it has many areas of application including medical, agricultural, food processing, nutritional enhancement, cosmetics, and waste and water treatment.
Chemical structure chitosan
Simulated body solution (SBF) is a solution with an ion concentration relatively similar to blood plasma, which is prepared under physiological body temperature and pH conditions. This solution was first used by Kokobo and his colleagues to investigate the changes on the surfaces of bioactive glass ceramics. This test is one of the common tests for investigating the bioactivity or biodegradability of biomaterials, and due to the ease of work and the lack of equipment and facilities, it has a wide range and high application, and at the same time, it provides decisive results for researches. has it.